![]() ![]() Near-death experience (NDE) has been reported in situations where the brain transitions toward death. Albeit the influence of neuronal injury and swelling, our data provide the first evidence from the dying human brain in a non-experimental, real-life acute care clinical setting and advocate that the human brain may possess the capability to generate coordinated activity during the near-death period. The strongest coupling is observed for narrow- and broad-band gamma activity by the alpha waves during left-sided suppression and after cardiac arrest. Cross-frequency coupling revealed modulation of left-hemispheric gamma activity by alpha and theta rhythms across all windows, even after cessation of cerebral blood flow. After cardiac arrest, delta, beta, alpha and gamma power were decreased but a higher percentage of relative gamma power was observed when compared to the interictal interval. An increase of absolute power in gamma activity in the narrow and broad bands and a decrease in theta power is seen after suppression of bilateral hemispheric responses. Here, we present continuous electroencephalography (EEG) recording from a dying human brain, obtained from an 87-year-old patient undergoing cardiac arrest after traumatic subdural hematoma. No study has yet investigated this matter in humans. Although a hypoactive state of brain activity has been assumed, experimental animal studies have shown increased activity after cardiac arrest, particularly in the gamma-band, resulting from hypercapnia prior to and cessation of cerebral blood flow after cardiac arrest. The neurophysiological footprint of brain activity after cardiac arrest and during near-death experience (NDE) is not well understood. 7Department of Neurosurgery, School of Medicine, University of Louisville, Louisville, KY, United States.6Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United States.5Epilepsy Program, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.4Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.3Division of Neurosurgery, Department of Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.2Institute of Computer Science, University of Tartu, Tartu, Estonia.1Department of Neurosurgery, Henan Provincial People’s Hospital, Henan University People’s Hospital, Henan University School of Medicine, Zhengzhou, China.Raul Vicente 1,2†, Michael Rizzuto 3†, Can Sarica 4, Kazuaki Yamamoto 4, Mohammed Sadr 3, Tarun Khajuria 2, Mostafa Fatehi 3, Farzad Moien-Afshari 5, Charles S. ![]()
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